{"id":15898,"date":"2025-02-15T01:00:00","date_gmt":"2025-02-15T01:00:00","guid":{"rendered":"https:\/\/onhee.com\/?p=15898"},"modified":"2025-02-15T01:00:00","modified_gmt":"2025-02-15T01:00:00","slug":"immobilized-coupling-reagents-synthesis-of-amides-peptides","status":"publish","type":"post","link":"https:\/\/onhee.com\/?p=15898","title":{"rendered":"Immobilized Coupling Reagents: Synthesis of Amides\/Peptides"},"content":{"rendered":"<p><strong>Immobilized Coupling Reagents: Synthesis of Amides\/Peptides\u00a0<\/strong>Cherkupally P, Ramesh S,\u00a0de La Torre BG,\u00a0Govender T,\u00a0Kruger HG, Albericio F, <em>ACS Comb. Sci.<\/em>, <strong>2014<\/strong> Article ASAP \u00a0<strong>Copyright \u00a9 2014 American Chemical Society<\/strong><\/p>\n<p>The primary idea of using immobilized reagents in organic synthetic chemistry is to simplify the downstream process, product workup and isolation, and therefore avoiding time-consuming and expensive chromatographic separations, which are intrinsic to every synthetic process. Numerous polymer-bounded reagents are commercially available and applicable to almost all kinds of synthetic chemistry conversions. Herein, we have covered all known supported-coupling reagents and bases which have had a great impact in amide\/peptide\u00a0bond formation. These coupling reagents have been used for the activation of a carboxyl moiety; thus generating an active acylating species that is ready to couple with an amine nucleophile liberating the amide\/peptide\u00a0and polymeric support which can be regenerated for reuse. This also addresses a large variety of anchored coupling reagents, additives, and bases that have only been employed in amide\/peptide\u00a0syntheses during the last six decades.<\/p>\n<p>&nbsp;<\/p>\n<div style=\"padding: 10px 0\">\n<p>Keyword: <a href=\"https:\/\/poolsupplies.cn\/\">pool products<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Immobilized Coupling Reagents: Synthesis of Amides\/Peptides\u00a0Cherkupally P, Ramesh S,\u00a0de La Torre BG,\u00a0Govender T,\u00a0Kruger HG, Albericio F, ACS Comb. Sci., 2014 Article ASAP \u00a0Copyright \u00a9 2014 American Chemical Society The primary idea of using immobilized reagents in organic synthetic chemistry is to simplify the downstream process, product workup and isolation, and therefore avoiding time-consuming and expensive &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/onhee.com\/?p=15898\" class=\"more-link\">Read more<span class=\"screen-reader-text\"> &#8220;Immobilized Coupling Reagents: Synthesis of Amides\/Peptides&#8221;<\/span><\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-15898","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/onhee.com\/index.php?rest_route=\/wp\/v2\/posts\/15898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onhee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/onhee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/onhee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15898"}],"version-history":[{"count":0,"href":"https:\/\/onhee.com\/index.php?rest_route=\/wp\/v2\/posts\/15898\/revisions"}],"wp:attachment":[{"href":"https:\/\/onhee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/onhee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/onhee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}